Our retrospective study found that Chinese patients with T2DM who initiated Basalin with pre-prandial insulin or OADs achieved further reductions in overall hyperglycemia, especially fasting hyperglycemia, after switching to Lantus (8.03 mmol/L vs. 7.30 mmol/L; p=0.0116) with a similar mean basal insulin dose (0.23 IU/kg/day vs. 0.24 IU/kg/day; p=0.8720). The gene discussed is INS; the disease is Hyperglycemia.