From our study, the analysis of the relationship between 2-year disease-free survival and high expression of TRKB/BDNF showed significantly higher rates of tumor recurrence in patients with TRKBhigh and/or BDNFhigh OSCC than in those suffering from TRKBlow/BDNFlow OSCC (Figure 2). The gene discussed is BDNF; the disease is neoplasm.