To investigate whether TRKB-selective inhibition could selectively suppress BDNFhigh/TRKBhigh PD-OSCC tumor growth in vivo, orthotopic transplantation of HSC-4 or HSC-3 into the tongues of BALB/cSlc-nu/nu mice was performed in the presence or absence of a TRKB specific inhibitor, ANA-12 (Figure 6). The gene discussed is NTRK2; the disease is neoplasm.