In this study, we revealed that the BDNF/TRKB signaling pathway, unlike other pathways related to the TRK family (TRKA and TRKC), contributes to OSCC tumor growth and invasion and therefore, identified these molecules as markers of MD/PD-OSCC tumor cells, which tend to infiltrate and metastasize into surrounding tissues. The gene discussed is NTRK3; the disease is neoplasm.