As shown in Figure 6C, tumor volume at the end of day 39 in mice injected with high salt passaged MCF-7s cells was 478 ± 79 mm3; while tumor volume in mice injected by SIK3-KO-MCF-7s cells on day 39 was 164 ± 57 mm3 (p < 0.05). The gene discussed is SIK3; the disease is neoplasm.