As shown in Figure 5A, tumor volume at the end of day 39 in mice injected with high salt passaged MCF-7s cells was 483 ± 64 mm3; while tumor volume in mice injected by Orai1-KO-MCF-7s cells on day 39 was 316 ± 72 mm3 (p < 0.05). This evidence concerns the gene ORAI1 and neoplasm.