For example, only four proteins (INCENP, MIS12, CDK1, COL5A1) were common in the list of aberration hubs identified through the same analysis applied to breast cancer (with total of 74 aberration hubs) and renal carcinoma datasets (with total of 47 proteins aberration hubs), indicating that AbHAC is capable of finding proteins that are specifically deregulated in a given cancer. The gene discussed is MIS12; the disease is breast carcinoma.