SYK and neoplasm: This was due to an aberrant splicing pattern introducing a new exon to SYK transcripts resulting in a longer isoform of the protein in tumor samples (SYK-L with 635 amino acids coded by transcripts ENST00000375754 and ENST00000375746) compared to a shorter isoform (SYK-S with 612 amino acids coded by transcripts ENST00000375751 and ENST00000375747) (Figure 3c and Supplementary Figure 4).