BRCA1 and breast cancer: Yao et al. identified 70 BRCA1 and 55 BRCA2 mutation-carrying families from 1,816 unselected Chinese women with breast cancer, and estimated the breast cancer risk by age 70 as 37.9% (95% CI: 24.1-54.4%) for BRCA1 and 36.5% (95% CI: 26.7-51.8%) for BRCA2 using a kin-cohort design [9].