The prevalence of BRCA mutations varies in different Asian cohorts, with 21.7% (BRCA1 9.3%; BRCA2 12.4%) in patients with family history of breast or ovarian cancer in Korea [18] and 17% (BRCA1 11%; BRCA2 6%) in Malaysian patients with early onset of breast cancer [19]. The gene discussed is BRCA1; the disease is breast carcinoma.