We knocked down PHLDA2 in ErbB2-positive NSCLC cells and demonstrated that PHLDA2 knockdown increased NSCLC cell growth and reduced sensitivity of the NSCLC cells to the ErbB2 tyrosine kinase inhibitor, lapatinib, consistent with its putative function as an AKT pathway inhibitor and suggestive of a candidate tumor suppressor function. This evidence concerns the gene ERBB2 and neoplasm.