Shimura et al. further demonstrate that, in prostate cancer specimens, CD68-positive macrophages are distributed in three distinguishable compartments (stroma, tumor cell region, and tumor-containing lumens), with 84% of macrophages being in the tumor-associated stroma and the remaining 16% in the tumor cell region and the lumens composed of tumor cells [53]. This evidence concerns the gene CD68 and Familial prostate cancer.