ICAM1 and coronary artery disorder: As one of the highest incidences of CVDs, coronary artery disease links with more than 20 targets in this T-cD network, such as VCAM1 and ICAM1 (reported to increase in dysfunctional endothelial cells [19]), MMP9, MMP3, and MMP2 (being influencing factors in cardiac fibrosis [20]).