Destabilization of TRAF2 by miR-17 leads to inhibition of TNF-α-induced NF-κB p65, c-Jun, and STAT3 nuclear translocation and the production of several essential proinflammatory cytokines and enzymes, including IL-6, IL-8, MMP-1, and MMP-13 in human RA FLS [34]. This evidence concerns the gene MMP1 and rheumatoid arthritis.