Alsaleh et al. showed that both DICER1 and global miRNAs were repressed in FLS from patients with RA [15]; The DICER1 repression led to induction of interleukin- (IL-) 6 production, a well-defined proinflammatory cytokine, in the RA FLS pretreated with lipopolysaccharide (LPS), suggesting that DICER1 repression could promote the inflammation status in FLS from RA patients. Here, DICER1 is linked to rheumatoid arthritis.