AKT1 and liver failure: The results showed that sophocarpine markedly downregulated the mRNA levels of PI3K and AKT (Figures 6(a) and 6(b)), and sophocarpine also reduced the mRNA levels of Bad, Bax-xL, Cyto-c, Apaf1, caspase-9, caspase-3, and caspase-6 in the liver of LPS-caused liver failure (Figures 6(c)–6(i)).