Moreover, JNK and Yorkie (Yki, a co-transcription factor inhibited by the Hippo pathway) mediated-upregulation of secreted factor dILP8 (Drosophila Insulin-Like Peptide 8), which inhibits the Ecdysone steroid hormone production from the prothoracic gland, results in the delayed larval-pupal transition caused by imaginal disc neoplastic tumours [94,118,119,120]. The gene discussed is MAPK8; the disease is neoplasm.