This agrees with data from men (57 years old), in a state of increased inflammation due to congestive heart failure (median TNFα concentration: 20.9 pg/mL), vitamin D3 supplementation decreased TNFα (median (IQR): −2.0 (−4.3, 5.5) pg/mL, p = 0.006) [44]. This evidence concerns the gene TNF and congestive heart failure.