CCNB1 and neoplasm: When the mice had a tumor size of 100 mm3, they were treated with 0.1 mL of PBS (as a control), free cyclin-B1 siRNA (100 μg), control siRNA Cyc-B3(50 μg), cyclin-B1-siRNA (5 μg and 10 μg) complexes with MPG-8/chol-MPG-8 at a 1/20 molar ratio and cyclin-B1 siRNA with MPG-8(10 μg) in every 3 days.