Antisense-VEGF-siRNA was encapsulated with polyplex (VEGF-siRNA-PEG) and polyethyleneimine (PEI) to form VEGF-siRNA-PEG/PEI PEC micelles to assess the tumor inhibitory effects for both intratumoral and intravenous administration in a prostate tumor model generated by subcutaneous injection of 1.5 × 106 PC-3 cells (human prostate cancer cells) into the flank of the mouse. The gene discussed is VEGFA; the disease is prostate carcinoma.