Survivin expression in normal tissue is low, but an aberrant expression of Survivin is found in various types of cancers, including esophageal, lung, ovarian, central nervous system, breast, colorectal, bladder, gastric, prostate, pancreatic, laryngeal, uterine, hepatocellular, renal cancers as well as sarcoma, melanoma and hematologic malignancies [158]. The gene discussed is BIRC5; the disease is renal carcinoma.