The autocrine effect of upregulated VEGF-C initiates several intracellular signaling pathways that mediate tumor progression in various cancers like ovarian cancer, breast cancer, bladder cancer and non-small cell lung cancer (NSCLC) [105,106,107,108,109,110,111,112,113,114,115,116,117,118,119]. The gene discussed is VEGFC; the disease is breast cancer.