In addition, to improve the antitumor activity of EphA2-targeted siRNA in ovarian cancer, combinatorial targeting of EphA2, Src and FAK (focal adhesion kinase) genes were made to downregulate the expression of FAK and Src (non-receptor tyrosine kinase) involved in tumor growth and aggressiveness in ovarian cancer [276,277,278,279,280,281,282]. This evidence concerns the gene PTK2 and ovarian carcinoma.