The anti-Bag-1-siRNA plasmid was combined with magnetic gold nanoparticles and evaluated its tumor inhibitory effects in colon cancer mouse model, developed by giving 1 × 106 of LoVo cell (human colon cancer cell lines) into the right flank of the Balb/C nude mice (14–16 g) of 4–5 weeks old. This evidence concerns the gene BAG1 and colonic neoplasm.