After 2 weeks of implantation, when the mice had a tumor volume of 20 mm3, the mice were treated with 100 μL of anti-RhoA (85 nM), anti-RhoC (85 nM) siRNA and cytofectin containing excipient as a control intratumarally at a 3-day interval over a period of 20 days. This evidence concerns the gene RHOA and neoplasm.