Due to the potential of Amaryllidaceae alkaloids in the clinical treatment of Alzheimer’s disease [3], as well as the activity of augustine against malaria [13], we decided to check the cholinesterase-acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)-inhibitory activities and the antiprotozoal capacity of six alkaloids isolated from C. amabile, including the two new alkaloids. Here, ACHE is linked to malaria.