A number of transcription factors including RUNX1, GATA2, GFI1, HOXA3, SOX17, and TAL1, and NOTCH, WNT, and BMP/TGF-β signaling have been implicated in control of HE and blood development (reviewed in Slukvin, 2016, Swiers et al., 2013b, Thambyrajah et al., 2016b). This evidence concerns the gene GFI1 and hereditary elliptocytosis.