However, critical factors involved in EHT, GFI1, and RUNX1 (Chen et al., 2009, Thambyrajah et al., 2016a) were downregulated in iG2−/− HE compared with iG2+/+ HE, and iG2−/− HE failed to undergo EHT. Here, RUNX1 is linked to hereditary elliptocytosis.