Conversely, genes that are differentially expressed between DS and euploid neurons and overexpressed independently of the APP gene copy number show high congruence with gene sets upregulated in DS at both days 45 and 65 (false discovery rate [FDR]-corrected p values <6 × 10−15 and <3 × 10−8, respectively, see Table S1), indicating that, in this in vitro model, Hsa21 genes other than APP drive many of the DS and AD pathogenic processes. Here, APP is linked to Dravet syndrome.