APP and Alzheimer disease: Our functional data indicating that tau phosphorylation and neuronal cell death were not affected by APP copy number or Aβ42 normalization are supported by our bioinformatics analyses that show that genes that change their behavior in an APP-dependent fashion in a Hsa21-trisomic background overlap with pathways related to abnormal nervous system development (Enrichr portal, MP0003632, p < 10−16) and abnormal brain morphology (MP0002152, p < 10−11) but not with AD (Table S1).