GPR35 and hypertensive disorder: The emerging roles of GPR35 in the cardiovascular system may implicate it as a novel contributor to cardiovascular dysfunction and a potential therapeutic target in cardiovascular disease, especially in hypertension and heart failure.1 Although GPR35 has been linked with cardiovascular disease, and a GPR35 knockout mouse has been reported to have an abnormal blood pressure phenotype, the consequences of GPR35 deficiency on cardiovascular function are yet to be examined thoroughly.