GPR35 and heart failure: In neonatal mouse cardiomyocytes, both Gpr35 messenger RNA and cell-surface protein levels were reported to increase in response to hypoxia and hypoxia-inducible factor 1 activation.15Gpr35 expression was induced in the myocardium of experimental mouse models of myocardial infarction and pathological hypertrophy, and preceded cardiac remodeling and heart failure.