Of note, SYN3/TIMP3 was also identified as susceptibility locus for age-related macular degeneration (Chen et al., 2010; Fritsche et al., 2016), a late-onset neurodegenerative disease of the retina involving amyloid-β pathology (Ratnayaka et al., 2015). The gene discussed is TIMP3; the disease is age-related macular degeneration.