Although the precise mechanism by which PrPC facilitates transport of iron to the AH is not clear from our data, a phenotype of relative iron deficiency in the cornea, CB, and retina of PrP−/− mice relative to PrP+/+ controls suggests that PrPC plays an essential role as in the outer retina (Asthana et al., 2017). Here, PRNP is linked to Iron deficiency anemia.