To evaluate whether the PrPC expressed in the cornea is susceptible to prion infection, transgenic mice expressing cervid PrPC (Kong et al., 2005) were inoculated with CWD-infected brain homogenate intracerebrally, and PrPC in the cornea and CB was evaluated for a possible change in conformation to the aggregated, PrP-scrapie isoform. The gene discussed is PRNP; the disease is scrapie.