PRTN3 and rheumatoid arthritis: Since 1998 she had suffered from RF and anti-citrullinated peptide antibodies (ACPA)-positive and erosive RA associated with rheumatoid nodules; she had been treated with several conventional and biological drugs (MTX, sulfasalazine, leflunomide, HCQ, infliximab, etanercept, adalimumab, rituximab, certolizumab, abatacept) plus prednisone (at a stable dose of 7.5 mg/day throughout the years); all of the drugs were discontinued for inefficacy or adverse events.