Finally, PRL-2 knock-down reduced the anchorage-independent growth and cell migration of human metastatic MDA-MB-231 breast cancer cells and reduced the cell migration and invasion of human A549 lung cancer cells, which can be rescued by co-transfecting an siRNA resistant PRL-2 (Y. Wang & Lazo, 2012). This evidence concerns the gene PTP4A2 and lung cancer.