Fifty eight applied a single equation; the most frequently used being the Modification of Diet in Renal Disease (MDRD) eq. (32 studies), followed by the Cockcroft-Gault formula (17 studies), the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula (7 studies), and the Cystatin C equation (two studies). The gene discussed is CST3; the disease is kidney disorder.