Importantly, Slit3 has been shown to suppress tumor growth of breast cancer in a mouse model [33] and impair cancer cell invasion and migration [24, 28, 34] through modulation of the expressions of E-cadherin, Vimentin, MMP2 and MMP9 [28].These findings demonstrate the tumor suppressive role of Slit3 in multiple types of tumor, although a comprehensive analysis addressing the clinicopathological and functional significances of Slit3 is still lacking. This evidence concerns the gene VIM and neoplasm.