Slit2 is frequently inactivated in human cancers including lung cancer [5], breast cancer [6, 7], colorectal cancer [8], ovarian cancer [9], glioma [10] and HCC [11, 12] and its tumor suppressive role that inhibits cancer cell invasion and migration [10, 13–17], angiogenesis [18, 19] and growth [8, 20–22], has been well-studied. The gene discussed is SLIT2; the disease is cancer.