To date, LC3B expression patterns in cancer are reported predominantly cytoplasmic [38, 39, 44–50], meanwhile other patterns such as large globule (stone) like structure and crescentic (perinuclear) patterns are also observed in oesophageal adenocarcinoma and triple negative breast cancer (TNBC) [39, 48]. The gene discussed is MAP1LC3B; the disease is esophageal adenocarcinoma.