As oropharyngeal and oral cavity SCC are distinctive SCC subgroups due to their different biology and management [11], a more definitive LC3B prognostic assessment between these malignancies would help to further establish their association with autophagy activity and thus assess the effectiveness of utilizing autophagy as a therapeutic strategy in oropharyngeal and oral cavity SCC. This evidence concerns the gene MAP1LC3B and oral cavity squamous cell carcinoma.