DKK3 and Familial prostate cancer: In this study, we show that the expression level of stromal Dkk-3 is also relevant to prostate cancer, and we identify two secreted proteins, TGFBI (Transforming Growth Factor Beta Induced) and ECM-1 (extracellular matrix protein 1), whose levels are differentially affected by DKK3 silencing in prostate stromal cells and that appear to play opposing roles in prostate cancer.