To investigate the function of stromal Dkk-3, we used the prostate stromal cell line WPMY-1, which is derived from the benign prostate of the same donor as RWPE-1 prostate epithelial cells and has been used as a model to investigate communication between prostate stromal cells and prostate epithelial and prostate cancer cells [18, 19]. This evidence concerns the gene DKK3 and prostate cancer.