The depletion of Tet1 and Tet2 may lead to hypermethylation of the P2rX7 promoter to block miR-297a-5p, miR-297b-5p, and miR-297C-5p release, leading to downregulation of Runx2 signaling and osteopenia phenotype. This evidence concerns the gene RUNX2 and Osteopenia.