In line with this, it has been shown that treatment with CpG ODN 1585 increased CXCL10 production and enhanced atherosclerosis in Apoe−/− mice.38 We show that the BAFF-TACI signaling pathway preferentially represses IRF7-mediated responses in TLR9-stimulated macrophages, leading to decreased Cxcl10 expression. The gene discussed is TNFRSF13B; the disease is atherosclerosis.