TNFRSF13C and atherosclerosis: B cell and humoral responses are decisively involved in the initiation and progression of atherosclerosis.2,3 In addition, genomic and transcriptomic data of participants of the Framingham study indicated proliferation and activation status of B cells to be key factors in determining cardiovascular disease (CVD) risk.4 The second most prominent candidate gene in this analysis was TNFRSF13C, which encodes 1 of the 3 known receptors for B cell–activating factor (BAFF), BAFF receptor (BAFFR).