TNFRSF13B and familial hypercholesterolemia: Notably, it has been reported that macrophages from TACI-deficient mice acquire an M2-like phenotype and display lower expression levels of TLR4 and TLR9.20 These data suggest that TACI signaling might enhance the proinflammatory properties of macrophages (eg, in situations of hypercholesterolemia).