In agreement with a B cell–independent role for BAFF in atherosclerosis, we found that atherogenic diet–fed Ldlr−/− mice with B cell–specific deletion of TACI, which did not alter splenic B cell numbers (Figure VA in online-only Data Supplement), or total cholesterol levels (Table I in online-only Data Supplement), did not impact atherosclerosis (Figure 5C). Here, TNFSF13B is linked to atherosclerosis.