These effects of anti-BAFF treatment on the B cell system are very similar to those described before in anti-CD20–treated and Baffr−/− models of atherosclerosis.2 Surprisingly, however, anti-BAFF Ab–treated mice developed larger atherosclerotic plaques (Figure 2A), which were further characterized by increased necrotic areas (Figure 2B) and decreased collagen content (Figure 2C), compared to Ctrl Ab–treated mice. Here, TNFSF13B is linked to atherosclerosis.