Furthermore, IgG antibodies—but not IgM—specific for the atherosclerosis-relevant oxidized low-density lipoprotein antigens malondialdehyde-modified low-density lipoprotein and CuSO4-oxidized low-density lipoprotein were also decreased in anti-BAFF–treated Apoe−/− mice (Figure 1E). The gene discussed is APOE; the disease is atherosclerosis.