CASP8 and malignant glioma: also reported that the hTERT promoter-operated expression of caspase-8 could significantly induce the apoptosis in hTERT-positive malignant glioma cells, but not in hTERT-negative astrocytes, fibroblasts, and alternative lengthening of telomeres cells, and significantly suppressed the growth of malignant glioma cells in the in vivo experimental setting.