The correlation of FLT3 and MDM2 levels and sensitivity to both idasanutlin and cobimetinib in AML cells may be based on these molecular mechanisms: MDM2 levels can be induced by FLT3 and FLT3-ITD via AKT, but also by activated RAS via MEK and ERK [28], while MDM2 mRNA export from the nucleus is dependent on MEK and MNK1 activity [29]. Here, FLT3 is linked to acute myeloid leukemia.