RUNX3 and acute myeloid leukemia: To demonstrate the induction of cell cycle arrest in AML cells with elevated levels of the cell cycle inhibitor CDKN1A, the cell cycle was analyzed by DNA content measurement employing flow cytometry in OCI-AML2 (Figure 2E and Figure S4A) and MOLM-13 cells (Figure 2F and Figure S4B) treated with single compounds or combined treatment.