IFNG and neoplasm: Oncolytic adenovirus Ad5-yCD/mutTKSR39rep-mIL12, which expresses two suicide genes and IL-12, induced high levels of IL-12 and IFN-γ in serum and tumor, increased natural killer (NK) and CTL lytic activities, and the developed tumor-specific antitumor immunity in prostate adenocarcinoma model, resulting in a significant increase in survival [74].