Recent studies have indicated that thiazole derivatives show significant antitumor activity against different cancer cell lines through the inhibition of histone deacetylases (HDACs), pro-matrix metalloproteinase activation, signal transducer and activator of transcription 3 (STAT3), Bcl-2 family, and kinases including Akt isoforms, aurora kinases, and cyclin-dependent kinases (CDKs) [17,18,19,20]. Here, AKT1 is linked to cancer.