Increased osteoclast differentiation and activity in SAO+ BM was speculatively linked to the increased transcription of SLC9A2, DLX3, TRPV4 and OMD.[27, 30, 36] The latter gene is up regulated in an osteoblast response to osteoclastic activity.[28] Results from GO analysis did not demonstrate biological functions associated with osteoclasts. The gene discussed is TRPV4; the disease is occult macular dystrophy.