We have previously evaluated an isocaloric/isolipidic (n-3) LC-PUFA supplementation upon adult WT and Cftr–/– mice infected chronically or acutely with P. aeruginosa. Five weeks administration of the (n-3) enriched diet decreased mortality and gel-forming Muc5b overexpression of infected WT mice, an increased distal alveolar fluid clearance and induced an increase in neutrophil flux and TNF-α release 24 hours post-infection (reviewed in Husson et al. [17]). Here, TNF is linked to infection.