The lack of proliferation activity of SMYD2 and SMYD3 inhibitors or SMYD2 and SMYD3 CRISPR knockout in any tested cell line, including many of those reported to be sensitive to SMYD2 or SMYD3 RNAi in the literature may suggest that the high expression level of SMYD2 and SMYD3 observed in a wide variety of cancers has another function than simply regulating cell growth. Here, SMYD3 is linked to cancer.