MAP2K4 and breast neoplasm: The sequencing of breast tumor genomic DNA has revealed mutations in genes that encode members of this pathway, including MAP3K1, MAP2K4, and MAP2K7 (Banerji et al., 2012; Cancer Genome Atlas Network, 2012; Ciriello et al., 2015; Ellis et al., 2012; Kan et al., 2010; Nik-Zainal et al., 2016; Shah et al., 2012; Stephens et al., 2012; Wang et al., 2014).