This role of JNK signaling is consistent with the discovery of frequent JNK pathway gene ablation and mutation in human breast cancer (Banerji et al., 2012; Cancer Genome Atlas Network, 2012; Ciriello et al., 2015; Ellis et al., 2012; Kan et al., 2010; Nik-Zainal et al., 2016; Shah et al., 2012; Stephens et al., 2012; Wang et al., 2014). The gene discussed is MAPK8; the disease is breast cancer.