Meanwhile, immunohistochemical staining showed that purified antihuman CT83 mAb 7G4 could react with endogenous human CT83 expressed in lung cancer, nasopharyngeal cancer, cervix cancer, colorectal cancer, breast cancer, gastric cancer, melanoma, urothelial carcinoma, and endometrioid adenocarcinoma tissues, whereby the positive immune reactive signals were located on cell membranes and in cytoplasm (Figure 3B). Here, CT83 is linked to melanoma.