Angiogenesis is a complex process involving in sustaining malignant microenvironment, tumor growth, and metastasis.14 VEGF family, PDGF, EGF, and fibroblast growth factor (FGF) play important roles in angiogenesis, in which VEGFA (VEGF) is the most important initiator of angiogenesis.15 The gene discussed is VEGFA; the disease is neoplasm.