Circ‐Foxo3 can bind to MDM2 and p53, promote MDM2‐induced p53 ubiquitination and subsequent degradation, and thus induce tumor cell apoptosis.45 In addition, circ‐Foxo3 can bind to stress‐related proteins and transcription factors, such as DNA‐binding protein inhibitor (ID‐1), E2F1, focal adhesion kinase (FAK), and HIF1α, thus promoting cardiac senescence.46 This evidence concerns the gene TP53 and neoplasm.