SHPRH and hepatocellular carcinoma: Hsa_circ_0001649 derived from the SHPRH gene is significantly downregulated in HCC samples and correlated with tumor size and the occurrence of tumor embolus.62 Yu et al63 revealed that the downregulation of hsa_circ_0001445 in HCC tissues is significantly correlated with aggressive characteristics and may serve as an independent risk factor for overall survival (OS) and recurrence‐free survival (RFS) in HCC patients after hepatectomy.