INS and obesity due to melanocortin 4 receptor deficiency: In a recent study by Morandi et al comprising 1076 children with obesity (mean age 11.4 years) and 1265 young adults with normal weight (mean age 21.1 years), no associations between a GRS comprising ten IR-associated SNPs and OGTT-derived traits (fasting insulin, fasting glucose and HOMA-IR) were identified [18].