TGFB1 and cancer: In TANs and TAMs, krasV12-induced up-regulation of pro-cancer inflammation genes (il1b and cxcl1) and down-regulation of anti-tumor cytokines (il12 and tnfα) and phagocytosis genes (mpx, lyz and mpeg) were also reverted with Tgfb signaling inhibition (Fig. 6D,E).