Consistent with previous reports3,48,49, infection with MCMV for 40 hours induced IL-18 in the serum (Fig. 4a) and led to MCMV-specific IFNγ production by splenic NK cells in wild-type controls, whereas these responses were dampened in Casp1/11−/− mice (Fig. 4a,d). The gene discussed is IFNG; the disease is infection.