Finally, WEE1 kinase could regulate CDK1 and CDK2 activity to facilitate DNA replication during S-phase and prevent unscheduled entry into mitosis, and cancers with defects in the FA and HR pathways may be targeted by WEE1 inhibition, which provides a basis for a novel SL strategy for cancers harboring FA/HR defects36. The gene discussed is WEE1; the disease is cancer.