As we show the ADAR1 controls the expression level of multiple transcription factors27, we hypothesized that ADAR1 controls the transcription of ITGB3. A segment of 1270 bp (−1120 to +50) of ITGB3 promoter6 was cloned into pGL4.14 luciferase reporter construct and transfected into all four melanoma lines with ADAR1-KD or control. Here, ITGB3 is linked to melanoma.