P2RX7 and cancer: In a comparison between mutated and wild-type P2X7 complex groups, we found that the mutated group was associated significantly more often (P = 0.035; Binomial test; Additional file 3: Figure S10) with improved prognosis (cox coefficient < − 0.1; 12 cancer types) than with poor prognosis (cox coefficient > 0.1; three cancer types).