In relation to the neuronal loss, we did observe that partial, but not complete loss of Tmem106b significantly lessened the extent of neuronal loss in the AAV-(GGGGCC)66 injected mice, suggesting that, if pursued, partial TMEM106B reduction may be a more viable avenue for future TMEM106B-related therapeutic approaches in FTD. The gene discussed is TMEM106B; the disease is frontotemporal dementia.