TMEM106B and frontotemporal dementia: To determine whether reduced Tmem106b levels might be protective against FTD-like behavioral phenotypes in the AAV-(GGGGCC)66 mouse model, the newborn Tmem106b +/+, +/−, and −/− mice were injected with either AAV- 66R or AAV-2R (control) and aged to 12 months of age.