DSC3 and neoplasm: As showed in Fig. 5a–c, xenografted (A549-SOX30(+)/DSP(−)), (A549-SOX30(+)/JUP(−)) and (A549-SOX30(+)/DSC3(−)) cells rapidly proliferated in mice compared with (A549-SOX30(+)) cells, and we found that tumor volume of (A549-SOX30(+)/DSP(−)), (A549-SOX30(+)/JUP(−)) and (A549-SOX30(+)/DSC3(−)) were significantly larger than those with (A549-SOX30(+)) cells.