Consistent with our theory, the protein expression of MMP7 and CCND1 were downregulated in a SOX30-overexpressing cell line and xenograft tumors; MMP7 and CCND1 expression were increased significantly in SOX30-overexpressing cells, or tumor tissue after DSP or JUP expression was blocked (Fig. 6a). Here, MMP7 is linked to neoplasm.