MAPT and Alzheimer disease: CBTAU-27.1 did not show immunoreactivity in either control or AD cases, whereas dmCBTAU-27.1 showed immunoreactivity in the cytosol of neurons of the control cases and clear recognition of aggregated tau in neuropil threads and NFTs in AD brains, but only after heat pretreatment which is a routine ‘antigen retrieval’ procedure to recover reactivity in formalin-fixed paraffin-embedded tissue sections.