Regarding the RPs of the large ribosome subunit, exome sequencing demonstrated the presence of mutations of RPL5 in T cell acute lymphoblastic leukemia (T-ALL) [108] and in glioblastoma [109], and loss of the 1p22.1 region encompassing the RPL5 gene was found in 20% of multiple myeloma cases (MM) [110]. Here, RPL5 is linked to Miyoshi myopathy.