EZH2 and malignant colon neoplasm: Recently, circular RNA (cirRNA) CCDC66 was shown to promote colon cancer cell growth and metastasis possibly by adsorbing miRNA, which had inhibited expression of several nuclear gene regulators, including DNA methyltransferase 3β (DNMT3B), enhancer of zeste homolog 2 (EZH2), c-Myc, and Yes-associated protein 1 (YAP1) [24].