DOCK8 and hyperinsulinemic hypoglycemia, familial, 4: The combined immunodeficiency due to DOCK8 deficiency (prevalence less than 1/1,000,000) is a form of autosomal recessive combined immunodeficiency (T, B and NK cells), characterized by recurrent lung infections, cutaneous viral infections, allergy, severe skin inflammation and susceptibility to cancer with a high level of IgE [10].